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Prof Shergill uses neuroimaging techniques to understand more about the brain mechanisms involved in the symptoms of schizophrenia – both the ‘positive symptoms’ (unusual experiences such as hallucinations and paranoia) that are characteristic of episodes of psychosis, and the cognitive and ‘negative’ symptoms that affect memory and attention, and make it difficult for people to interact socially and sustain relationships.
He aims to use that knowledge to aid the development of new, effective treatments for the large number of people with schizophrenia who do not respond to antipsychotic medication. 20 to 45 per cent of patients experience significant ‘positive’ symptoms despite optimal antipsychotic treatment, and cognitive and ‘negative’ symptoms are largely unresponsive to conventional treatment.
Professor Shergill studied medicine and psychology at University College London. He started his psychiatry training at University College London and completed it at the Maudsley Hospital London. He received his research training at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London and the Functional Imaging Lab at the Institute of Neurology at University College London. He has been the recipient of several competitive research fellowships and awards.
He is head of the Cognition, Schizophrenia and Imaging Laboratory (CSI Lab), housed in the Department of Psychosis Studies at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London. His research is carried out in collaboration with the lab's junior researchers and students; with clinicians who are keen to get involved in research and use the results to inform their practice; and with affiliated colleagues based in universities around the world.