Project Details page

Exclusion Criteria

1. Evidence or history of clinically significant haematological, renal, endocrine, pulmonary, gastrointestinal,
cardiovascular, hepatic, neurologic, or allergic disease (including drug allergies, but excluding untreated,
asymptomatic, seasonal allergies at time of dosing), and any primary psychiatric diagnosis other than bipolar disorder
or major depressive disorder.
2. Recent influenza vaccination.
3. Treatment with an experimental medicine drug within one month preceding the first study day, over the course of the
study.
4. A positive urine drug screen on or after the screening visit during their active involvement in the study for opiates,
methadone, cocaine, amphetamines (including MDMA), barbiturates, benzodiazepines and cannabinoids.
5. Participants who, in the opinion of the investigator, have any medical or psychological condition or social
circumstances which would impair their ability to participate reliably in the study, or who may increase the risk to
themselves or others by participating.
6. Diagnosis of alcohol or drug dependence in the year prior to recruitment or diagnosis of harmful use of alcohol or
drugs within the previous 6 months (excluding nicotine).
7. Female participants that are currently pregnant or are breast feeding.
8. A history of moderate to severe head injury or neurological conditions that may impair cognitive performance.
9. Ineligibility to undergo MRI imaging, for example the presence of a cardiac pacemaker or other electronic device or
ferromagnetic metal foreign bodies as assessed by a standard pre-MRI questionnaire.
10. Participant weight in excess of 126kg or physical dimensions such that the participant may not fit in the MRI
scanner.
11. A history of claustrophobia or participant feels unable to lie in an MRI scanner for a period of around one hour.
12. Any other reason that in the opinion of the investigator may impact the safety of participants or the integrity of the
data.
Additional exclusion criteria for participants with bipolar disorder or major depressive disorder
13. Currently taking any psychotropic medication.
14. No evidence of anhedonia (as measured by a score of 0 on the anhedonia question of the HAM-D questionnaire).
15. Current manic state (as measured by a score of > 8 on the YMRS).
Additional exclusion criteria for healthy participants
16. A personal history of any significant psychiatric disorder including a history of suicide attempts or significant
suicidal ideation or a family history in first degree relatives of severe mental illness (such as psychosis, bipolar
disorder or schizophrenia).