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SNAPPER: A stratified randomised controlled trial to evaluate the clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit/hyperactivity disorder and a history of Psychosis or biPolar disordER

Overview

Do you have bipolar or psychosis? Do you also have, or think you might have, untreated ADHD?

ADHD is a common mental disorder that involves problems with attention, overactivity and acting impulsively. People tend to associate ADHD with childhood but it often continues into adults. It is usually treated with medication.

SNAPPER is a study looking at which of two types of medication works best at reducing the effects of ADHD in adults with psychosis or bipolar disorder. You could help our research by taking part in the SNAPPER study.

Why take part?
Doctors don’t know yet which medications for ADHD work best in people who also have psychosis or bipolar. We hope this study will help treatment of people with these conditions in the future.

For further information, please visit the SNAPPER Research Team Website: www.birmingham.ac.uk/snapper

Are you interested in taking part in this study? 

Find out more by filling in this form

Planned end date

31 May 2027 23:59

Conditions

ADHD,Bipolar Disorder,Psychosis,Schizophrenia

Inclusion Criteria

  • Diagnosis of ADHD according to the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) based on the
  • Diagnostic Interview for ADHD in Adults-5 (DIVA-5)
  • Psychosis (schizophrenia spectrum disorders) (Strata 1) OR Bipolar disorder (Strata 2) diagnosis according to the DSM-5 based on the Mini International Neuropsychiatric Interview (MINI)
  • Stable and on suitable mood stabilisers or antipsychotics
  • Males and females aged 18 years and over
  • Not currently (or within the last month) on medication for ADHD
  • Able to give written informed consent

Exclusion Criteria

  • ADHD medication contra-indicated
  • Currently in an acute episode of psychosis or bipolar disorder
  • Severe suicide risk or severe risk of violence to others
  • Severe drug seeking behaviour or a current drug/alcohol withdrawal syndrome
  • History of epilepsy or seizures
  • Congenital or acquired long QT syndrome (LQTS); OR family history of QT prolongation; OR on medication associated with increased risk of QT interval prolongation such as class IA and III anti-arrhythmics,moxifloxacin,erythromycin,methadone,mefloquine,tricyclic antidepressants or cisapride.
  • Currently taking CYP2D6 inhibitors e.g.,quinidine,terbinafine.
  • Participating in another interventional or conflicting/incompatible clinical trial
  • Females of child-bearing age only:
  • Pregnant. Note: Spot urine test will be performed at screening and/or randomisation to rule out pregnancy in females of child-bearing age
  • Not willing to take highly effective contraceptive measures to prevent pregnancy during study participation period AND for 30 days following administration of the last trial medication dose.
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